Berberine: Strongest supplement in the world?

There are an infinite variety of supplements on the market.

Many of them have been proven to work, while others were ineffective.

Berberine is one that really works.

You can literally the most powerful natural supplement on earth.

In fact, it is one of the few ^[1] supplements also proven effective as a drug.

This is a detailed study of berberine and its impact on health.

What's berberine?

Berberine is a bioactive compound that can be extracted from various plants, including a group called shrubs Berberis ( 1 ).

Technically, berberine belongs to a class of compounds called alkaloids ^[2] . It has a yellow color, and often has been used as a colorant.

Berberine has to deal with a long history of use in traditional Chinese medicine, where it was used different diseases.

(Now, modern science has that berberine impressive benefits for various health problems confirmed 2 ).

Conclusion: Berberine is a compound which can be extracted from various plants. It has a long history of use in traditional Chinese medicine.

As berberine works?

Berberine has now been tested on hundreds of different studies.

It has been shown that strong effects on many different biological systems (having 3 ).

After eating berberine, he is captured by the body and transported into the bloodstream. Then, moved to the body's cells.

In cells, berberine occurs various molecular targets "," and various changes in the function ( 4 ). This is similar to drugs at work.

I will not go into detail, because here the biological mechanisms of berberine are complex and diverse.

However, one of the most important measures of berberine, an enzyme in cells that activate AMPK ^[3] (AMPK) ( 5 ).

This enzyme is sometimes referred to as a "metabolic master switch" ( 6 ).

It is in the cells of various organs, including the brain, muscle, kidney, heart and liver. This enzyme plays an important role in the regulation of metabolism ( 7 , 8 ).

Berberine also affects several other molecules ^[4] within cells, and can even affect the genes that are activated or deactivated ( 4 ).

Conclusion: The berberine acts on the body at the molecular level and has a variety of functions within the cells. A major feature is the activation of an important enzyme called AMPK, which regulates metabolism.

Berberine caused a significant reduction in blood glucose levels, comparable to drugs

Type 2 diabetes is a serious disease, which in recent decades increasingly what millions of deaths every year.

It is characterized by high blood sugar (glucose), either due to insulin resistance or insulin deficiency identified.

Over time, can damage tissues and organs, a high blood sugar levels, leading to various problems and a shorter life.

Many studies show that berberine significantly reduce blood sugar levels in people with type 2 diabetes ( 9 ).

In fact, its efficiency is comparable to the popular diabetes drug metformin ^[5] (Glucophage) ( 2 , 10 ).

Berberine seems to work by different mechanisms ( 11 )

• Lowers insulin resistance, blood sugar lowering hormone insulin more effectively.
• Glycolysis increases, helps the body break down sugars in the cells.
• Reduce the sugar production in the liver.
• Slows the breakdown of carbohydrates in the intestine.
• Increases the number of beneficial bacteria ^[6] in the intestine.
• This is just the tip of the iceberg. Berberine may also affect other enzymes related molecules and genes that glucose.

In a study of 116 patients with diabetes, one gram per day berberine reduced the blood glucose concentration by 20%, from 7.0 to 5.6 mmol / l (126-101 mg / dL), diabetes to normal values ​​( 12 ).

It also reduces 12% HbA1c (a marker of blood sugar levels in the long term), and also an improved blood fats such as cholesterol and triglycerides ( 12 ).

Following a review of 14 studies berberine is as effective as oral diabetes medications, including metformin, glipizide and rosiglitazone ( 13 ).

It works very well with lifestyle changes, and also has additive effects when combined with other hypoglycemic drugs (administered 2 ).

If you are looking for online discussions, you will often see people with exorbitant sugar levels normalize literally berberine.

This really works, both in the school and the real world.

Conclusion: Berberine is very effective in reducing blood glucose and HbA1c levels, which are elevated in people with diabetes. Works and some medicines.

Berberine can help you lose weight

Berberine may also be effective weight loss supplement ^[7] .

So far, two studies ^[8] studied the effects of berberine on body weight.

In a 12-week study in obese people, berberine 500 mg three times daily weight loss of about five pounds have caused on average. In addition, participants lost 3.6% of their body fat ( 14 ).

An impressive study was conducted on 37 men and women with metabolic syndrome. The study lasted 3 months, participants took berberine 300 mg, 3 times daily.

The participants lowered their levels of body mass index (BMI) from 31.5 to 27.4, and obesity overweight in just three months. Also you lose belly fat ^[9] and the improvement of many health indicators ( 15 ).

Researchers believe that the weight loss is due to the improvement of the regulatory function of fat hormones such as insulin, adiponectin and leptin ^[10] .

Berberine appears to inhibit (the growth of fat cells at the molecular level 16 , 17 ).

Conclusion: Two studies have shown that berberine may cause significant weight loss and improves all kinds of other health markers simultaneously.

Berberine lowers cholesterol and may increase the risk of heart disease

Heart disease is currently the leading cause of premature death.

Many factors can be measured in the blood are associated with an increased risk of heart disease associated.

As it stands, berberine has been shown that some of these factors improve.

Following a review of 11 studies, berberine may ( 18 )

• Low total cholesterol by 0.61 mmol / L (24 mg / dL).
• Lower LDL-cholesterol ^[11] of 0.65 mmol / l (25 mg / dL).
• Low blood triglycerides by 0.50 mmol / L (44 mg / dL).
• Increasing HDL cholesterol 0.05 mmol / l (2 mg / dl).

Berberine has also been shown to reduce apolipoprotein B ^[12] 13 to 15%, which is a very important risk factor (is 19 , 20 ).

According to some studies, berberine works by inhibiting an enzyme called PCSK9 ^[13] . This leads to LDL from the circulation (deleted 21 , 22 ).

Note that diabetes, high blood sugar and obesity are also risk factors for heart disease, which all seem to be improved with berberine.

Given the positive impact on all of these risk factors, it seems likely that berberine could significantly reduce the risk of heart disease.

Conclusion: Studies show that berberine lowers cholesterol and triglycerides, and increases HDL ("good cholesterol") cholesterol. Berberine can reduce long-term risk of heart disease.

Other health benefits of berberine

Berberine may also many other health benefits:

• Depression: Studies in rats show that this fight depression (help 23 , 24 , 25 ).
• Cancer test tube and animal studies have shown that berberine can reduce the growth and various cancers (distributed 26 , 27 ).
• Anti-oxidant and anti-inflammatory: berberine have shown that strong antioxidant and anti-inflammatory in some studies ( 28 , 29 , 30 ).
• Infections: The berberine has shown that combating harmful microorganisms such as bacteria, viruses, fungi and parasites ( 31 , 32 , 33 , 34 ).
• Foie gras: the berberine can reduce the accumulation of fat in the liver, which (should reduce the protection against non-alcoholic fatty liver disease (NAFLD) 35 , 36 ).
• Heart failure: A study has shown that berberine significantly improved symptoms and the risk of death in patients with heart failure (reduced 37 ).

Many of these benefits requires more research before we can make strong recommendations, but the current evidence is very promising.

Conclusion: Preliminary studies indicate that berberine may have benefits for depression, cancer, infections, fatty liver disease and heart failure. It has powerful antioxidant and anti-inflammatory.

Dosage and side effects

Many of the studies cited in section doses used in the range of 900 to 1500 mg per day.

It is common to take 500 mg, 3 times a day before meals (total of 1500 mg per day).

Berberine has a half-life of several hours, it is necessary several times to distribute the dose per day to achieve stable blood levels.

If you have a medical condition or are taking medication, then it is recommended that you talk to your doctor before taking berberine.

This is especially important if you are taking drugs to lower glucose.

Generally has a remarkable safety profile berberine. The main side effects are to digestion related, and there are reports of cramps, diarrhea, bloating, constipation and abdominal pain ( 10 ).

Conclusion: A common recommendation dose is 500 mg, 3 times a day, half an hour before meals. Berberine can cause gastrointestinal side effects in some people.

Where to buy berberine

Although berberine has attracted much attention in the scientific literature that has not yet reached the "mainstream" of popularity, received.

For this reason, it is not widely available in supermarkets and shops complement.

However, there is a good selection of berberine supplements available on Amazon ^[14] .

I personally took a brand called Glycosolve . I'm with the guys to produce are both doctors who have used with very good results in their patients know.
^[15]

Conclusion: The berberine is not supplemented in shops or supermarkets widespread, but can be purchased from online retailers like Amazon.

Top news

Berberine is one of the few supplements that are as effective as a drug.

It has a major impact on various aspects of health, especially control of blood sugar.

Those who benefit most people with type 2 diabetes and metabolic syndrome are.

However, it can also supplement as a general protection against chronic diseases as well as anti-aging.

If you can use supplements and berberine be one of the above belong to their arsenal.

I personally have met for a few weeks now to improve overall health.

I intend to continue to play, and I'm eager to see more research on this incredibly powerful substance promoting health.

Credentials

1. ^{^} rarely (authoritynutrition.com)
2. ^{^} alkaloids (en.wikipedia.org)
3. ^{^} AMP-activated protein kinase (en.wikipedia.org)
4. ^{^} other molecules (examine.com)
5. ^{^} metformin (www.webmd.com)
6. ^{^} beneficial bacteria (authoritynutrition.com)
7. ^{^} weight loss supplement (authoritynutrition.com)
8. ^{^} two studies (hardcoretrainingsolutions.com)
9. ^{^} lost abdominal fat (authoritynutrition.com)
10. ^{^} leptin (authoritynutrition.com)
11. ^{^} LDL (www.docsopinion.com)
12. ^{^} apolipoprotein B (www.docsopinion.com)
13. ^{^} PCSK9 (en.wikipedia.org)
14. ^{^} Amazon (www.amazon.com)
15. ^{^} Glycosolve (www.amazon.com)